Structure of PDB 8vzv Chain DDD

Receptor sequence
>8vzvDDD (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILW
ELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTAL
DFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEE
NELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF
IRIQAESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQ
GALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSSG
YHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLE
3D structure
PDB8vzv Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
ChainDDD
Resolution2.29 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM DDD F72 H76 Y79 F83 L132 S151 G152 F153 F158 R159 H328 M331 V332 Y350 L351 F34 H38 Y41 F45 L94 S113 G114 F115 F120 R121 H288 M291 V292 Y303 L304
BS02 ZIQ DDD R103 E105 W208 R211 T212 P213 F304 R65 E67 W170 R173 T174 P175 F264
BS03 A1AER DDD F72 H76 R144 A150 F34 H38 R106 A112
External links
PDB RCSB:8vzv, PDBe:8vzv, PDBj:8vzv
PDBsum8vzv
PubMed39106326
UniProtP48775|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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