Structure of PDB 8br5 Chain DDD

Receptor sequence
>8br5DDD (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEFGVVYKGYVNNTTVAVKKL
ATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSL
LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD
EAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFG
VVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST
SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8br5 Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 .
ChainDDD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R73 DDD M192 V200 A211 K213 V246 Y262 V263 Y264 M265 G268 L318 M29 V35 A46 K48 V76 Y92 V93 Y94 M95 G98 L148
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8br5, PDBe:8br5, PDBj:8br5
PDBsum8br5
PubMed38228402
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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