Structure of PDB 7zx0 Chain DDD

Receptor sequence
>7zx0DDD (length=633) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIDDGFPIKGCDDTLV
VGLAVCWGGRDAYYFSLQKVPPSLDPSLTLKDRMWYLQSCLRKESDKECS
VVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS
FLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLN
SLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLD
AIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHP
LPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRI
TFTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELR
ILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICY
GIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRD
GFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVN
IQKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQI
VKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
3D structure
PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
ChainDDD
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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