Structure of PDB 7q5w Chain DDD

Receptor sequence
>7q5wDDD (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA
HGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP
FNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEK
LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALC
LLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLT
VPCQKIG
3D structure
PDB7q5w The tandem SH2 domains of SYK
ChainDDD
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide DDD R22 R42 H63 Y64 T65 I76 A77 G78 G98 R175 R195 R197 H215 Y216 R217 I228 E230 G231 K232 K247 D249 G250 L251 R16 R36 H57 Y58 T59 I70 A71 G72 G92 R169 R189 R191 H209 Y210 R211 I222 E224 G225 K226 K241 D243 G244 L245
BS02 peptide DDD H62 Y64 G98 H56 Y58 G92
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5w, PDBe:7q5w, PDBj:7q5w
PDBsum7q5w
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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