Structure of PDB 7q5t Chain DDD

Receptor sequence
>7q5tDDD (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR
KAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR
PQGVQPKTGPFEDLKENLIREYVKQTWNALEQAIISQKPQLEKLIATTAH
EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKV
LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIG
3D structure
PDB7q5t The tandem SH2 domains of SYK
ChainDDD
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide DDD R22 R42 R45 H63 Y64 T65 D97 G98 R175 R195 R197 H215 Y216 R217 I228 P229 E230 G231 K232 K247 D249 G250 R13 R33 R36 H54 Y55 T56 D88 G89 R162 R182 R184 H202 Y203 R204 I215 P216 E217 G218 K219 K234 D236 G237
BS02 peptide DDD E67 A77 E58 A68
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5t, PDBe:7q5t, PDBj:7q5t
PDBsum7q5t
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

[Back to BioLiP]