Structure of PDB 7akr Chain DDD

Receptor sequence
>7akrDDD (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
SSLSRFRGCLAGALLGDCVGSFYAAHDTVDLTSVLRHVQSLEPTEALYYT
DDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKK
LLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARL
SAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDA
QSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFES
VPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIA
GAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQ
3D structure
PDB7akr Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.
ChainDDD
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG DDD T76 D77 D78 D316 T50 D51 D52 D290
BS02 MG DDD D314 D316 T317 D288 D290 T291
BS03 AR6 DDD D77 D78 G117 A118 G119 V120 F143 S148 Y149 G150 N151 G152 H182 I271 D314 D316 T317 D51 D52 G91 A92 G93 V94 F117 S122 Y123 G124 N125 G126 H156 I245 D288 D290 T291
BS04 AR6 DDD G115 I271 G89 I245
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
GO:0061463 O-acetyl-ADP-ribose deacetylase activity
GO:0140292 ADP-ribosylserine hydrolase activity
Biological Process
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0060546 negative regulation of necroptotic process
GO:0071451 cellular response to superoxide
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016604 nuclear body
GO:0090734 site of DNA damage

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Molecular Function
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Cellular Component
External links
PDB RCSB:7akr, PDBe:7akr, PDBj:7akr
PDBsum7akr
PubMed34321462
UniProtQ9NX46|ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (Gene Name=ADPRS)

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