Structure of PDB 6hiw Chain DD

Receptor sequence

>6hiwDD (length=791) Species: 5702 (Trypanosoma brucei brucei)

HRSGKARAFVFRDPSLRMMRAGSGYQQLRRMGMPMQVGMGWRKVDSFHAN
TQYQHAWPLLSHDDLGNSDQSNNTKNIMYSMYMPKRNKGTAPWFRGADTY
SVKYCEQGRYEYQRYLMINRFPSEYKKHFLSFLSNIRMSSGSATIPQEAL
HWLLRMIVDNFNPQHVHYIAAMKTLQSAGELDMARDVWKIMERQQTWPCT
ATICAYLDVCVEAGEKTWAMEAWNRYCTELKFLEPGEVDPKPISRVPFSL
TREELLYLPKWKKHFDHDPNLDVMDLNRFNRTREVYLRMAQVMLAGGERN
AFQHFFTKLEEAMLNKPTPVPEPPNPHLVRRPRWAPYEHCKSVHHSPWRL
QNNGRALALGPPVTIEDEMQSRFFSNDQFLVHSVKEVLRIVLQEHKRAHP
TECTRCKTEAFFYKTKDADETLKFCDDLIERLFASLGVRLSNLNTSSLLS
TILEVFRVVGKESGAALLQRANEFLERKASLGDAEGSRENLTASNYLQVL
SGFADESAFVYNTKKDGTCQYKTGFDPRTTMRHLADVVQEIAGNPHVTWA
ADMHLQVVETMVGCGTMKANDYFVRNVLRQFSWDSRFLEALYVEYRRQDD
VDMWAELTKRALVWTARYNAPASERLRRLIEDDYDTIRVQTRTFRELAVF
QFRDVEERRHSRDVVNELPNPWYDYVAHALPFPDRDAGYPDEYGDLGQWR
APGGPGSPVRGPRGYTAEWRDLRNPMRPPEFPTPWERKYRQYARGQHPSY
DMVYAGPMPEIFPMRRDFRKPTRWDFHDIEKQGKYRTSGPY

3D structure

• PDB: 6hiw Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
• Chain: DD
• Resolution: 3.37 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	DD	H10 R11 S12 K14 A15 R16 A17 R21 M27 R29 Y34 M44 V46 G47 G49 W50 K52 F56 H57 G75 R95 K97 D107 T108 Y109 S110 K136 S140 S143 S151 A152 R339 R342 Q707 W708 A710 Y763 D772 M773 K805	H1 R2 S3 K5 A6 R7 A8 R12 M18 R20 Y25 M35 V37 G38 G40 W41 K43 F47 H48 G66 R86 K88 D98 T99 Y100 S101 K127 S131 S134 S142 A143 R330 R333 Q698 W699 A701 Y742 D751 M752 K784

Gene Ontology

Biological Process

• GO:0000963 mitochondrial RNA processing

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0031019 mitochondrial mRNA editing complex

External links

• PDB: RCSB:6hiw, PDBe:6hiw, PDBj:6hiw
• PDBsum: 6hiw
• PubMed: 30213880
• UniProt: Q385L8