Structure of PDB 4u20 Chain D3

Receptor sequence

>4u20D3 (length=64) Species: 83333 (Escherichia coli K-12)

PKIKTVRGAAKRFKKTGKGGFKHKHANLRHILTKKATKRKRHLRPKAMVS
KGDLGLVIACLPYA

3D structure

• PDB: 4u20 Synergy of streptogramin antibiotics occurs independently of their effects on translation.
• Chain: D3
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D3	P2 K3 I4 K5 R8 K12 R13 T17 G18 K19 K23 H26 A27 N28 R30 H31 I32 L33 T34 K35 T38 K39 R40 K41 R42 H43 L44 R45 K47 S51 K52 G53 D54 Y64	P1 K2 I3 K4 R7 K11 R12 T16 G17 K18 K22 H25 A26 N27 R29 H30 I31 L32 T33 K34 T37 K38 R39 K40 R41 H42 L43 R44 K46 S50 K51 G52 D53 Y63

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4u20, PDBe:4u20, PDBj:4u20
• PDBsum: 4u20
• PubMed: 24957822
• UniProt: P0A7Q1|RL35_ECOLI Large ribosomal subunit protein bL35 (Gene Name=rpmI)