Structure of PDB 8ape Chain D1

Receptor sequence

>8apeD1 (length=487) Species: 5702 (Trypanosoma brucei brucei)

VADHKGRVGHVSQVIGAVVDVHFADGVPPVLTALDVVDKLGRDEPLTLEI
VQHLDAHTGRCIAMQTTDLLKLKAKVVSTGGNISVPVGRETLGRIFNVLG
DAIDQRGPVGEKLRMPIHAVAPKLADQAAEDAVLTTGIKVIDLILPYCKG
GKIGLFGGAGVGKTVIIMELINNVAKGHGGFSVFAGVGERTREGTDLYLE
MMQSKVIDLKGESKCVLVYGQMNEPPGARARVAQSALTMAEYFRDVEGQD
VLLFIDNIFRFTQANSEVSALLGRIPAAVGYQPTLAEDLGQLQERITSTT
KGSITSVQAVYVPADDITDPAPATTFSHLDATTVLDRAVAESGIYPAVNP
LECASRIMDPDVISVDHYNVAQDVVQMLTKYRELQDIIAVLGIDELSEED
KLIVDRARKLVKFLSQPFQVAEVFTGMTGHYVQLDDTIDSFSGLLMGTYD
QVPEMAFYMVGGINSVLEKAKKMAEEAAELEKMRRAR

3D structure

• PDB: 8ape An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases.
• Chain: D1
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number: 7.1.2.2: H(+)-transporting two-sector ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	D1	A185 G186 G188 K189 T190 V191 Y371	A159 G160 G162 K163 T164 V165 Y345

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
• GO:0046961 proton-transporting ATPase activity, rotational mechanism

Biological Process

• GO:0006754 ATP biosynthetic process
• GO:0015986 proton motive force-driven ATP synthesis
• GO:0042776 proton motive force-driven mitochondrial ATP synthesis
• GO:0046034 ATP metabolic process
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

External links

• PDB: RCSB:8ape, PDBe:8ape, PDBj:8ape
• PDBsum: 8ape
• PubMed: 36220811
• UniProt: Q9GPE9|ATPB_TRYBB ATP synthase subunit beta, mitochondrial (Gene Name=Tb427.03.1380)