Structure of PDB 9fe0 Chain D

Receptor sequence

>9fe0D (length=416) Species: 224324 (Aquifex aeolicus VF5)

SYPAIPRIYAETTLNMLLKRAKKPRVHSIDEYLKDGGYQALEKALNMSPE
EIIDWVDKSTLRGGGGAGFPTGKKWKFAVQNPGPRYFICNADESEPGTFK
DRIIIERDPHLLIEGIIISSYAIGANEAYIYIRGEYPAGYYILRDAIEEA
KKKGFLGKNILGSGFDLEIYVARGAGAYICGEETALIESLEGKRGHPRLK
PPYPVQKGLWGKPTVVNNVETIANVPFIISMGWEEYRYIGPSDYAGPKLF
PVSGKVKKPGVYELPMNTTLREVIFKYAGGTLGNKKVKAVFSGALDCFSS
EELDIPMDYSPLGFGGTGTVIVLTEEDDIVEAALKIAEFYEHETCGQCTP
CRVGCYEQANLLEKIYKGEATEQDWEGFDFVNRNIQPTSICGLGAVAGRL
IRQTLEKFPEEWEKYR

3D structure

• PDB: 9fe0 Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
• Chain: D
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	D	P199 T346 C347 G348 Q349 C350 C353 I392 C393 L395 G396	P197 T344 C345 G346 Q347 C348 C351 I390 C391 L393 G394
BS02	FNR	D	G65 G67 K76 N92 D94 E95 G183 E184 E185 N219 N220 T223	G63 G65 K74 N90 D92 E93 G181 E182 E183 N217 N218 T221
BS03	NAD	D	G67 G68 A69 F71 K76 E95 E97 Y180 E185 Y205	G65 G66 A67 F69 K74 E93 E95 Y178 E183 Y203

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:1902600 proton transmembrane transport

External links

• PDB: RCSB:9fe0, PDBe:9fe0, PDBj:9fe0
• PDBsum: 9fe0
• PubMed: 38960077
• UniProt: O66841|NUOF_AQUAE NADH-quinone oxidoreductase subunit F (Gene Name=nuoF)