Structure of PDB 9eqg Chain D

Receptor sequence

>9eqgD (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]

DNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDME
YTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVA
HNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS
YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGE
YVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG
VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY
FTKRGYAWDGKSVVPEKKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATY
LNR

3D structure

PDB

9eqg A brain-to-gut signal controls intestinal fat absorption.

Chain

Resolution

2.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MAN	D	N111 P115 K117	N102 P106 K108
BS02	PGW	D	I223 V227 N408 W412	I214 V218 N343 W347
BS03	A1H6W	D	H102 V203 S205 S206 T207 Y210	H93 V194 S196 S197 T198 Y201
BS04	PT5	D	R249 S299 E303 F310 K312 R313 S388 S390 K391 I392 L395 S396 A399 F400 L403	R240 S290 E294 F301 K303 R304 S323 S325 K326 I327 L330 S331 A334 F335 L338

External links

PDB	RCSB:9eqg, PDBe:9eqg, PDBj:9eqg
PDBsum	9eqg
PubMed	39261733
UniProt	P14867\|GBRA1_HUMAN Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=GABRA1)

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