Structure of PDB 9bc6 Chain D

Receptor sequence
>9bc6D (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]
MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRF
YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMN
FRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGR
ALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLI
GMLLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKA
MSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDS
SRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNE
LNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYI
IREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTAS
VRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETV
3D structure
PDB9bc6 Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
ChainD
Resolution2.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PFL D L305 C309 M356 Y386 F389 L203 C207 M254 Y284 F287
External links
PDB RCSB:9bc6, PDBe:9bc6, PDBj:9bc6
PDBsum9bc6
PubMed39085604
UniProtO60741|HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Gene Name=HCN1)

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