Structure of PDB 8zly Chain D

Receptor sequence

>8zlyD (length=501) Species: 171101 (Streptococcus pneumoniae R6)

MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAKLIEAGA
NTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFE
GEAKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVL
VDDGKLGLRVVAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAE
RDNDDIRFGLEQGINFIAISFVRTAKDVNEVRAICEETGNGHVQLFAKIE
NQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIIKKVNAAGK
VVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPL
ESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVKDATSSMDI
KLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
APSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTV
R

3D structure

• PDB: 8zly Structural basis of nucleotide selectivity in pyruvate kinase.
• Chain: D
• Resolution: 1.89 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FBP	D	S382 T384 T407 K408 T409 H411 T412 V490 R491	S382 T384 T407 K408 T409 H411 T412 V490 R491
BS02	MG	D	E250 D274	E250 D274
BS03	UDP	D	L11 P13 R54 N56 H59 R95 K184 S340 G341 N345	L11 P13 R54 N56 H59 R95 K184 S340 G341 N345
BS04	OXL	D	K248 E250 A271 G273 D274 T306	K248 E250 A271 G273 D274 T306

Gene Ontology

Molecular Function

• GO:0004743 pyruvate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006096 glycolytic process
• GO:0016310 phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:8zly, PDBe:8zly, PDBj:8zly
• PDBsum: 8zly
• PubMed: 39009072
• UniProt: Q8DQ84