Structure of PDB 8yp3 Chain D

Receptor sequence

>8yp3D (length=466) Species: 7108 (Spodoptera frugiperda) [Search protein sequence]

HMSYDSIFENLNSHGQGHLLKYWPDLSEKERAQLLNDLKKIDFAEVNELF
RRANDDLKPIPDSHYEAVPNLSNEKILEYENIGLREISDGKVGVLLLAGG
QATRLGFGHPKGMYDVGLPSRKTLFQIQAERIVRVQQMAAEKYGKEGKIT
WYIMTSEHTRGPTADYFRSHNYFGLNEEDIVYFEQGTLPCFDFEGKIFLD
EKYHVSSAPDGNGGLYRALKNQGVLDDIAKRGVEHLHAHSVDNILIKVAD
PVFIGYCKSKNADCAAKVVQKSTPSEAVGVVCRHYKVVEYSELTDEAAES
RTADGRLTFSAGNICNHYFSSEFLTKICNFESKLKLHVAKKKIPYVDHEG
VRQKPTEPNGIKMEKFIFDVFEFAENFICLEVARDVEFSALKNNDAAKKD
CPSTAREDLLRLHRKYVREAGGIVEDNIDVEISPLLSYGGENLTDLVSGE
VFTISPYHLKSMQESA

3D structure

PDB

8yp3 Structure and Inhibition of Insect UDP- N -acetylglucosamine Pyrophosphorylase: A Key Enzyme in the Hexosamine Biosynthesis Pathway.

Chain

Resolution

2.12 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UD1	D	L113 G115 G116 Q201 G227 N228 S256 V257 V294 G295 E308 Y309 N332 F387 K411	L97 G99 G100 Q185 G211 N212 S240 V241 V278 G279 E289 Y290 N313 F368 K392
BS02	MG	D	N332 C334 H336	N313 C315 H317

External links

PDB	RCSB:8yp3, PDBe:8yp3, PDBj:8yp3
PDBsum	8yp3
PubMed	39039661
UniProt	A0A2H1VI03

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