Structure of PDB 8yhw Chain D

Receptor sequence
>8yhwD (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
EEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLT
EKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRL
EVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKE
QGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALC
DFGHAVCLYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPW
TQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAE
LGGKVNRALQQVGGLKSPWRGEYKEPRHP
3D structure
PDB8yhw The Crystal Structure of NF-kB-inducing Kinase (NIK) from Biortus
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS D G407 G409 F411 V414 K429 M469 L472 D519 L522 D534 G536 G74 G76 F78 V81 K96 M136 L139 D186 L189 D201 G203
BS02 MG D N520 D534 N187 D201
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8yhw, PDBe:8yhw, PDBj:8yhw
PDBsum8yhw
PubMed
UniProtQ99558|M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (Gene Name=MAP3K14)

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