Structure of PDB 8wyg Chain D

Receptor sequence
>8wygD (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
KLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPM
DLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQD
VFEFRYAKMP
3D structure
PDB8wyg Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
ChainD
Resolution3.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHN D W370 P371 F372 V376 D377 L381 N429 V435 M438 W26 P27 F28 V32 D33 L37 N85 V91 M94
External links
PDB RCSB:8wyg, PDBe:8wyg, PDBj:8wyg
PDBsum8wyg
PubMed38175809
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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