Structure of PDB 8wue Chain D

Receptor sequence
>8wueD (length=225) Species: 8355 (Xenopus laevis) [Search protein sequence]
GRSVDTMALWLGLRAVLVVAGLAVLLQLIRGWLSSKSYVFNREEIARLAK
EHSGLDYEVAFSKIIVELRKKHPGHILQDEDLQWVFVNAGGWMGSMCLLH
ASLTEYVLLFGTAVDTGGHSGRYWAEISDTILSGTFRQWKEGTTKSEIFY
PGDTIVHEVGEATSVQWSSGTWMVEYGRGFIPSTLAFALADTIFSTQDFL
TLFYTVKVYSKALLLEASTHLSQLG
3D structure
PDB8wue Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
ChainD
Resolution3.089 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZWY D W86 M90 Y100 Y117 W161 E169 T178 L179 A182 W92 M96 Y106 Y123 W167 E175 T184 L185 A188
Gene Ontology
Biological Process
GO:0006869 lipid transport
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:8wue, PDBe:8wue, PDBj:8wue
PDBsum8wue
PubMed38965213
UniProtQ6DCU6|SGMR1_XENLA Sigma non-opioid intracellular receptor 1 (Gene Name=sigmar1)

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