Structure of PDB 8w7f Chain D

Receptor sequence
>8w7fD (length=412) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DYDLVVVGGGIVGAASAREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVI
HAGIYYKPGTLKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEKEVK
LLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQGVMALHSPHTGIVDWGL
VTEHYGQDFKQCGGDIYLDFNVSKFTETKETDYPVTIHGAKPGQTVRTKN
VLTCGGLQSDLLAEKTGCPRDPRIVPFRGEYLLLTKEKQHMVKGNIYPVP
DPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINLFELFDALRY
PGFVKMASKYIGFGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGV
RAQAMDLDGNLVDDFVFDRGQGSGALAKRVLHCRNAPSPGATSSLAIAKM
IADKIENEFSIG
3D structure
PDB8w7f Structure and biochemical characterization of L-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of L-2-hydroxyglutaric aciduria
ChainD
Resolution2.299 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.99.2: L-2-hydroxyglutarate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D G51 I52 V53 E74 K75 H82 Q83 S84 H86 N87 S88 V90 H92 V213 G247 Q250 Y273 R393 P431 G432 A433 T434 G10 I11 V12 E33 K34 H41 Q42 S43 H45 N46 S47 V49 H51 V172 G205 Q208 Y231 R351 P389 G390 A391 T392
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0047545 2-hydroxyglutarate dehydrogenase activity
GO:0061758 2-hydroxyglutarate dehydrogenase activity, forward reaction
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Cellular Component
External links
PDB RCSB:8w7f, PDBe:8w7f, PDBj:8w7f
PDBsum8w7f
PubMed37995940
UniProtQ9VJ28

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