Structure of PDB 8w2h Chain D

Receptor sequence

>8w2hD (length=761) Species: 9606 (Homo sapiens) [Search protein sequence]

ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGI
TNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAG
LVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGR
HCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNII
IIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDR
ILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAP
AAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLG
RGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEA
RGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSAS
GTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEH
MTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVI
GLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAA
YVSGELEHVTR

3D structure

PDB

8w2h Structural basis for allosteric regulation of human phosphofructokinase-1.

Chain

Resolution

2.6 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FBP	D	R565 R654	R555 R644
BS02	FBP	D	R470 T527 S529 M572 H660 R734	R460 T517 S519 M562 H650 R724
BS03	ATP	D	Q197 R419 R423 G457 R461	Q187 R409 R413 G447 R451
BS04	ATP	D	G24 G25 Y55 R88 C89 F92 G118 D119 G120 S121 G124 I127	G14 G15 Y45 R78 C79 F82 G108 D109 G110 S111 G114 I117
BS05	ATP	D	W227 L228 W382 Y385 K386 K392	W217 L218 W372 Y375 K376 K382

External links

PDB	RCSB:8w2h, PDBe:8w2h, PDBj:8w2h
PDBsum	8w2h
PubMed	39183237
UniProt	P17858\|PFKAL_HUMAN ATP-dependent 6-phosphofructokinase, liver type (Gene Name=PFKL)

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