Structure of PDB 8w0t Chain D

Receptor sequence
>8w0tD (length=398) Species: 9606 (Homo sapiens) [Search protein sequence]
EERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKA
GEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGP
GFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQ
GIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGISL
FLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFY
YIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQH
KLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYD
CVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK
3D structure
PDB8w0t Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases.
ChainD
Resolution2.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D R317 F320 L327 G389 R285 F288 L295 G357
BS02 FAD D M172 T173 G178 S179 F203 S205 V407 Y411 T414 E416 I417 M140 T141 G146 S147 F171 S173 V375 Y379 T382 E384 I385
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016401 palmitoyl-CoA oxidase activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006631 fatty acid metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042413 carnitine catabolic process
GO:0042758 long-chain fatty acid catabolic process
GO:0044242 cellular lipid catabolic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0046322 negative regulation of fatty acid oxidation
GO:0090181 regulation of cholesterol metabolic process
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w0t, PDBe:8w0t, PDBj:8w0t
PDBsum8w0t
PubMed38839792
UniProtP28330|ACADL_HUMAN Long-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADL)

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