Structure of PDB 8vyx Chain D

Receptor sequence
>8vyxD (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTSMMGLLTNLADRELVHMINW
AKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLL
DRNQGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLK
SLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHM
SNKGMEHLYSMKCKNVVPSYDLLLEMLD
3D structure
PDB8vyx Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu.
ChainD
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AHU D M343 L346 T347 A350 E353 L387 I424 M33 L36 T37 A40 E43 L77 I109
External links
PDB RCSB:8vyx, PDBe:8vyx, PDBj:8vyx
PDBsum8vyx
PubMed38830107
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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