Structure of PDB 8vtq Chain D

Receptor sequence

>8vtqD (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]

LIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWE
LDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALD
FNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEEN
ELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFI
RIQAEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQ
GALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKS
GYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFL

3D structure

PDB

8vtq Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.05 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	A1ADX	D	Y42 Y45	Y3 Y6
BS02	HEM	D	F72 H76 Y79 F140 S151 G152 F153 F158 R159 Y175 H328 M331 V332 Y350 L351	F33 H37 Y40 F101 S112 G113 F114 F119 R120 Y136 H288 M291 V292 Y304 L305
BS03	ZIQ	D	R103 E105 W208 R211 T212 P213 F304 P307	R64 E66 W169 R172 T173 P174 F264 P267
BS04	A1ADX	D	F72 H76 F140 R144 S148 P149 A150	F33 H37 F101 R105 S109 P110 A111

External links

PDB	RCSB:8vtq, PDBe:8vtq, PDBj:8vtq
PDBsum	8vtq
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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