Structure of PDB 8vlb Chain D

Receptor sequence
>8vlbD (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
VLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQ
YRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKET
LFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLH
LYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP
3D structure
PDB8vlb A small molecule VHL molecular glue degrader for cysteine dioxygenase 1
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.20: cysteine dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JF D W47 F53 Q99 P150 W42 F48 Q94 P145
BS02 FE2 D H86 H88 H140 H81 H83 H135
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016151 nickel cation binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0017172 cysteine dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0000097 sulfur amino acid biosynthetic process
GO:0006534 cysteine metabolic process
GO:0006954 inflammatory response
GO:0007595 lactation
GO:0019448 L-cysteine catabolic process
GO:0033762 response to glucagon
GO:0042412 taurine biosynthetic process
GO:0043200 response to amino acid
GO:0045471 response to ethanol
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8vlb, PDBe:8vlb, PDBj:8vlb
PDBsum8vlb
PubMed
UniProtQ16878|CDO1_HUMAN Cysteine dioxygenase type 1 (Gene Name=CDO1)

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