Structure of PDB 8vis Chain D

Receptor sequence
>8visD (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
ILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPR
DWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTK
DIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDV
CNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGI
VSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGIEFVE
3D structure
PDB8vis Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
ChainD
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D H227 S266 H269 Y316 A363 C364 Q365 G366 S368 V387 S388 W389 G390 H41 S80 H83 Y130 A177 C178 Q179 G180 S182 V201 S202 W203 G204
BS02 peptide D S197 F284 T285 K286 H289 S290 V291 C292 E375 R379 W381 S11 F98 T99 K100 H103 S104 V105 C106 E189 R193 W195
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8vis, PDBe:8vis, PDBj:8vis
PDBsum8vis
PubMed
UniProtO60235|TM11D_HUMAN Transmembrane protease serine 11D (Gene Name=TMPRSS11D)

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