Structure of PDB 8v84 Chain D

Receptor sequence
>8v84D (length=423) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence]
VEKFEELKLSQPTLKAIEKMGFTTMTSVQARTIPPLLAGRDVLGAAKTGS
GKTLAFLIPAIELLHSLKFKPRNGTGIIVITPTRELALQIFGVARELMEF
HSQTFGIVIGGANRRQEAEKLMKGVNMLIATPGRLLDHLQNTKGFVFKNL
KALIIDEADRILEIGFEDEMRQIIKILPNEDRQSMLFSATQTTKVEDLAR
ISLRPGPLFINVQGYVVCDSDKRFLLLFSFLKRNQKKKIIVFLSSCNSVK
YYAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAERGILICTDVAARGL
DIPAVDWIIQFDPPDDPRDYIGKSLMFLTPNELGFLRYLKASKVPLNEYE
FPENKIANVQSQLEKLIKSNYYLHQTAKDGYRSYLQAYASHSLKTVYQID
KLDLAKVAKSYGFPVPPKVNITI
3D structure
PDB8v84 The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna D N153 R155 Q156 E159 K160 Y437 R448 N486 N113 R115 Q116 E119 K120 Y371 R382 N420
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008186 ATP-dependent activity, acting on RNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:1990417 snoRNA release from pre-rRNA
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0030687 preribosome, large subunit precursor
GO:0032040 small-subunit processome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v84, PDBe:8v84, PDBj:8v84
PDBsum8v84
PubMed38632236
UniProtQ03532|HAS1_YEAST ATP-dependent RNA helicase HAS1 (Gene Name=HAS1)

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