Structure of PDB 8v6n Chain D

Receptor sequence
>8v6nD (length=636) Species: 9606 (Homo sapiens) [Search protein sequence]
PVFSKPMDSNIRQCRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDED
VPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRF
INAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPK
YQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHAL
VTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGK
AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSV
LEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNI
TLTLVSYYRPREEEGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQS
ILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY
TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKD
NKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILT
FVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRF
RMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNE
3D structure
PDB8v6n TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
ChainD
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACD D I528 S576 I579 Q580 I413 S461 I464 Q465
BS02 FZ4 D H417 L420 H426 L429 H430 R693 H314 L317 H323 L326 H327 R578
BS03 FZ4 D S444 W493 C496 K500 S341 W378 C381 K385
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v6n, PDBe:8v6n, PDBj:8v6n
PDBsum8v6n
PubMed38691614
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

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