Structure of PDB 8uy1 Chain D

Receptor sequence
>8uy1D (length=592) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
NAMHIRDMLAEAERTGEPSFSFQYFPPKTAQGVQNLYDRMERMYNYGPKF
IDITWGAGGRVAELTCEMVVQAQAYLGLETCMHLTCTDMGVERINDALRK
AYKAGCTNILALRGDPPEAAKDGFRYAKDLVAHIRKEYGDHFDIGVAGYP
EGCDDNKDEDLLLDHLKEKVDMGAGFIVTQMFYDVDNFLRWVKKVRERGI
SVPIVPGIMPIATYASFLRRANHMKCKIPEEWMAKLEPVKNDDVAVREIG
KTLVADMCRKILDAGIRHLHFYTMNLAQATRMVLEELNWLPSPDRPLKHA
LPWKQSLGFGRRGEDVRPIFWRNRNKSYVARTQDWDEFPNGRWGDSRSPA
FGELDAYGVGLTGSNEQNRERWGEPKCIRDIANLFIRYMRKEIDYLPWSE
APVADEADLIKDELIDLNRRGLITVNSQPAVNGAKSNHPVHGWGPSNGYV
YQKAYLEFFVSPELYPEIKRRIESHPDLTYHAVTKSGNLETNAQSDGPNA
VTWGVFPGKEIFQPTIVERISFLAWKDEAYHLGMEWARCYDAGSPSRVLL
EEMMNTWWLVNIVNNDFHQGNTLFEILKGLEVTDLDKVPETQ
3D structure
PDB8uy1 Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.
ChainD
Resolution3.49 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D T52 W53 H81 T83 L110 R111 G112 D113 Y130 A131 A151 Y153 N160 H169 K173 T54 W55 H83 T85 L112 R113 G114 D115 Y126 A127 A147 Y149 N156 H165 K169
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
Biological Process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uy1, PDBe:8uy1, PDBj:8uy1
PDBsum8uy1
PubMed38886362
UniProtG0S5U9

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