Structure of PDB 8un3 Chain D

Receptor sequence
>8un3D (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
STEYKLVVVGAGDVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB8un3 Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors
ChainD
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XOI D G12 E62 E63 Y64 R68 D69 M72 D92 H95 Y96 Q99 V103 G12 E62 E63 Y64 R68 D69 M72 D92 H95 Y96 Q99 V103
BS02 GDP D D13 G15 K16 S17 A18 F28 D30 K117 D119 S145 A146 K147 D13 G15 K16 S17 A18 F28 D30 K117 D119 S145 A146 K147
BS03 MG D S17 D33 S17 D33
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8un3, PDBe:8un3, PDBj:8un3
PDBsum8un3
PubMed38229748
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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