Structure of PDB 8umy Chain D

Receptor sequence
>8umyD (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
AKPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGK
TSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGS
RSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVS
RIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVS
EGDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSG
SFDKLEAVVKDLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEV
DKCLADGADEHLQLISLCATVMQQLSQNC
3D structure
PDB8umy Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.
ChainD
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D I116 R120 I82 R86
BS02 AGS D R164 R193 R130 R159
BS03 MG D T85 D150 T51 D116
BS04 AGS D V41 R45 A53 P80 G81 T82 G83 K84 T85 S86 N181 L238 R239 V7 R11 A19 P46 G47 T48 G49 K50 T51 S52 N147 L204 R205
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8umy, PDBe:8umy, PDBj:8umy
PDBsum8umy
PubMed38669181
UniProtP35249|RFC4_HUMAN Replication factor C subunit 4 (Gene Name=RFC4)

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