Structure of PDB 8uk9 Chain D

Receptor sequence
>8uk9D (length=318) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
ITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPS
PGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQ
KVIVIDEFCRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQSR
CRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKNF
PDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLESLKNKDVKQLR
ALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANT
ELHLAYLFIQLACEMQWK
3D structure
PDB8uk9 Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D K80 I81 R85 K79 I80 R84
BS02 MG D T57 D107 E108 T56 D106 E107
BS03 AF3 D K56 E108 N139 R205 K55 E107 N138 R204
BS04 ADP D E12 R16 P17 I24 G53 T54 G55 K56 T57 F204 R205 E11 R15 P16 I23 G52 T53 G54 K55 T56 F203 R204
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0005663 DNA replication factor C complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uk9, PDBe:8uk9, PDBj:8uk9
PDBsum8uk9
PubMed38177685
UniProtP04526|LOADL_BPT4 Sliding-clamp-loader large subunit (Gene Name=44)

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