Structure of PDB 8ui8 Chain D

Receptor sequence
>8ui8D (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
KPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKT
STILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSR
SDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSR
IIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSE
GDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSGS
FDKLEAVVKDLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVD
KCLADGADEHLQLISLCATVMQQLSQNC
3D structure
PDB8ui8 Cryo-EM map of human clmap-clamp loader ATAD5-RFC-two PCNAs complex in intermediate state 3
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP D V41 R45 V52 A53 G81 T82 G83 K84 T85 S86 R210 L238 R239 V6 R10 V17 A18 G46 T47 G48 K49 T50 S51 R175 L203 R204
Gene Ontology
Molecular Function
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ui8, PDBe:8ui8, PDBj:8ui8
PDBsum8ui8
PubMed38871854
UniProtP35249|RFC4_HUMAN Replication factor C subunit 4 (Gene Name=RFC4)

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