Structure of PDB 8u16 Chain D

Receptor sequence
>8u16D (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFA
VLAYSQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQ
SDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKSYKWWQKYQKRK
FHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFS
YRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEI
TTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWF
PGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIP
3D structure
PDB8u16 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
ChainD
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C323 C326 C391 C394 C242 C245 C310 C313
BS02 Y70 D N351 P352 H378 W380 W386 W400 F402 N270 P271 H297 W299 W305 W319 F321
External links
PDB RCSB:8u16, PDBe:8u16, PDBj:8u16
PDBsum8u16
PubMed38086859
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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