Structure of PDB 8u15 Chain D

Receptor sequence
>8u15D (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFA
VLAYAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQ
QAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSYKWWQKYQKRKFHC
ANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRV
AACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTK
NEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGY
AWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTVILCL
3D structure
PDB8u15 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
ChainD
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C323 C391 C394 C239 C307 C310
BS02 8W7 D N351 P352 H378 W380 W386 W400 F402 N267 P268 H294 W296 W302 W316 F318
External links
PDB RCSB:8u15, PDBe:8u15, PDBj:8u15
PDBsum8u15
PubMed38086859
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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