Structure of PDB 8tvm Chain D

Receptor sequence
>8tvmD (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVK
KLAEELKQQDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLL
DRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE
AFTAKISDFTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIIT
GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSV
ASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8tvm A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
ChainD
Resolution2.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VDC D M192 A211 Y262 V263 Y264 M265 P266 G268 L318 D329 M29 A48 Y91 V92 Y93 M94 P95 G97 L147 D158
External links
PDB RCSB:8tvm, PDBe:8tvm, PDBj:8tvm
PDBsum8tvm
PubMed38746903
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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