Structure of PDB 8tqp Chain D

Receptor sequence
>8tqpD (length=214) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PIVQNLQGQMVHQCISPRTLNAWVKVVEEKAFSPEVIPMFSALSCGATPQ
DLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVGPIAPGQMREPRGS
DIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYSPTSILD
IRQGPKEPFRDYVDRFYKTLRAEQASQEVKNTETLLVQNANPDCKTILKA
LGPATLEEMMTACQ
3D structure
PDB8tqp Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators.
ChainD
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K3L D R173 K182 N183 R171 K180 N181
BS02 K3L D N53 L56 N57 M66 Q67 K70 I73 A105 G106 T107 Y130 N53 L56 N57 M66 Q67 K70 I73 A103 G104 T105 Y128
Gene Ontology

View graph for
Biological Process
External links
PDB RCSB:8tqp, PDBe:8tqp, PDBj:8tqp
PDBsum8tqp
PubMed38054267
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

[Back to BioLiP]