Structure of PDB 8to4 Chain D

Receptor sequence
>8to4D (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT
SPKKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVR
EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI
TDFGVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPAS
EISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKM
ARDPQRYLVIQGDERMHLSPTDSNFYRALMDEE
3D structure
PDB8to4 EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057
ChainD
Resolution2.99 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D N842 D855 N139 D152
BS02 ANP D G719 G721 A743 K745 M790 Q791 M793 D837 R841 N842 L844 D855 G18 G20 A42 K44 M87 Q88 M90 D134 R138 N139 L141 D152
BS03 IXR D V726 A743 K745 I759 M766 C775 L788 M790 D855 F856 V25 A42 K44 I56 M63 C72 L85 M87 D152 F153
External links
PDB RCSB:8to4, PDBe:8to4, PDBj:8to4
PDBsum8to4
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

[Back to BioLiP]