Structure of PDB 8to3 Chain D

Receptor sequence
>8to3D (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
ALLRILKETEFKKIKVLGSGAFTVYKGLWIPEGEKVKIPVAIKELREATS
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMD
3D structure
PDB8to3 EGFR(T790M/V948R) in complex with LN5461
ChainD
Resolution2.49 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D N842 D855 N140 D153
BS02 ANP D G719 G721 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844 D855 G18 G20 V24 A41 K43 M88 M91 C95 D135 R139 N140 L142 D153
External links
PDB RCSB:8to3, PDBe:8to3, PDBj:8to3
PDBsum8to3
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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