Structure of PDB 8tkh Chain D

Receptor sequence
>8tkhD (length=2268) Species: 9606 (Homo sapiens) [Search protein sequence]
SSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRD
CLFKVCPMNRYSAQKQYWKAKQTDVVLLQKLQHAAQMEQKQNDTENKKVH
GDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWL
FIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNS
VNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYKGKLQ
VFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATG
NYLAAEENPSIKYCLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRL
RHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEI
RDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNN
GQNVLDIMVTKPNRERQKLMREQNILKQVFGILKAPFRPLVRLEELSDQK
NAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTI
TALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNHIAI
PVTQELICKCVLDPKNSDILIRTELRPVEEEVWLTWTDKNNEHHEKSVRQ
LAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISQQLGVDLI
FLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAI
TIKDYDSNLNASRDDKKNKFANTMEFVEDYLNNVVSEAVPFANEEKNKLT
FEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCVTMVLSRKQSVFSAPS
LSAENEDIVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPN
MNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLIHLTMHDYAPLVS
GALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVE
KSELWVSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDL
LQIPYDKGDAKMMEILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTPGLL
EAETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKA
EGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDH
SPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEV
KMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMARVCSKREKRV
ADPTLEKYVLSVVLDTINAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLL
ECPWLQQQHKGSVEACIRTLAMVAKGRAILLPMDLDAHISSMLSWDYKNI
IEKLQDIITALEERLKPLVQAELSVLVDVLHWPELLFLEGSEAYQRCESG
GFLSKLIQHTKDLMESEEKLCIKVLRTLQQMLLKKTKYGDRGNQLRKMLL
QNYLQNRDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIH
LLDGGNTEIQKSFHNLMMSDKKSERFFKVLHDRMKRAQQETKSTVEMGTS
VLIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCG
STTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNG
IDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERI
LISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQ
LQHLLKPVEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPGICQFLTEETK
HRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRKLRSMPLIYWFSRRMT
LWGSISFNLAVFINIIIAFFYPYMSIRPLIVALILRSIYYLGIGPTLNIL
GALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLF
AHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSI
VGFLFLKDDFILEVDRLPDSTERACDTLLMCIVTVMNHGLRNGGGVGDIL
RKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKK
EEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNK
TDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSNEGEGEQNEIRILQDKLN
STMKLVSHLTAQLNELKE
3D structure
PDB8tkh Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor.
ChainD
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C2538 H2558 H2563 C2158 H2178 H2183
BS02 I3P D T268 R270 K507 R568 K569 T256 R258 K468 R523 K524
BS03 ATP D F2539 I2559 K2560 H2563 N2564 M2565 W2566 F2159 I2179 K2180 H2183 N2184 M2185 W2186
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0005216 monoatomic ion channel activity
GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015278 intracellularly gated calcium channel activity
GO:0035091 phosphatidylinositol binding
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007613 memory
GO:0019722 calcium-mediated signaling
GO:0030168 platelet activation
GO:0050909 sensory perception of taste
GO:0050913 sensory perception of bitter taste
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051289 protein homotetramerization
GO:0051592 response to calcium ion
GO:0055074 calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0060291 long-term synaptic potentiation
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031095 platelet dense tubular network membrane
GO:0031410 cytoplasmic vesicle
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tkh, PDBe:8tkh, PDBj:8tkh
PDBsum8tkh
PubMed37898605
UniProtQ14573|ITPR3_HUMAN Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 (Gene Name=ITPR3)

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