Structure of PDB 8tdr Chain D

Receptor sequence
>8tdrD (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GSAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMV
RHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYE
GTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLES
NPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIA
KFSKVRTDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQR
LLGRSWSVPVIRHLFAPLKEYFACV
3D structure
PDB8tdr Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain
ChainD
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH D F640 D641 G642 T645 S663 E664 V665 D686 V687 G707 R891 S892 W893 F15 D16 G17 T20 S38 E39 V40 D61 V62 G82 R254 S255 W256
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8tdr, PDBe:8tdr, PDBj:8tdr
PDBsum8tdr
PubMed38600075
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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