Structure of PDB 8t7d Chain D

Receptor sequence

>8t7dD (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]

SKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDA
TNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRN
ILGGTVFREAIICKNIPRLVSGWVKPIIIGRHTDFVVPGPGKVEITYTPS
DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYL
STKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAM
KSFIWACKYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETS
TNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDL
AACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK

3D structure

PDB

8t7d Mechanistic and Biostructural Studies of Mutant IDH1

Chain

Resolution

3.444 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZT3	D	A111 I113 W124 I128 M291	A110 I112 W123 I127 M265

External links

PDB	RCSB:8t7d, PDBe:8t7d, PDBj:8t7d
PDBsum	8t7d
PubMed
UniProt	O75874\|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

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