Structure of PDB 8t50 Chain D

Receptor sequence
>8t50D (length=474) Species: 9606 (Homo sapiens) [Search protein sequence]
NKFSLRMFGSQKAVEKEQERVKTADFRFYWDLIMLIMMVGNLVIIPVGIT
FFTEQTTTPWIIFNVASDTVCLLDLIMNFRDPKVIKMNYLKSWFVVDFIS
SIPVDYIFLIVEKGRALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHM
TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDSWGKQYSYALFKA
MSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDS
SRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNE
LNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYI
IREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTAS
VRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILL
QKFQNQENEILKQIVKHDREMVQA
3D structure
PDB8t50 Structural basis for hyperpolarization-dependent opening of human HCN1 channel.
ChainD
Resolution3.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP D M530 G539 E540 I541 C542 R549 T550 R590 I594 M378 G387 E388 I389 C390 R397 T398 R438 I442
Gene Ontology
Molecular Function
GO:0005222 intracellularly cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0022843 voltage-gated monoatomic cation channel activity
GO:0030552 cAMP binding
GO:0042802 identical protein binding
GO:0140232 intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0006814 sodium ion transport
GO:0019228 neuronal action potential
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045176 apical protein localization
GO:0046549 retinal cone cell development
GO:0051289 protein homotetramerization
GO:0051867 general adaptation syndrome, behavioral process
GO:0060078 regulation of postsynaptic membrane potential
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0034702 monoatomic ion channel complex
GO:0045211 postsynaptic membrane
GO:0048787 presynaptic active zone membrane
GO:0098855 HCN channel complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t50, PDBe:8t50, PDBj:8t50
PDBsum8t50
PubMed38890331
UniProtO60741|HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Gene Name=HCN1)

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