Structure of PDB 8t4m Chain D

Receptor sequence
>8t4mD (length=533) Species: 9606 (Homo sapiens) [Search protein sequence]
MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRF
YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMN
FRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGR
ALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLI
GMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKA
MSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDS
SRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNE
LNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYI
IREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTAS
VRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILL
QKFQKDLNTGVFNNQENEILKQIVKHDREMVQA
3D structure
PDB8t4m Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel
ChainD
Resolution3.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP D M530 F538 G539 I541 R549 T550 A551 R590 I594 V633 M428 F436 G437 I439 R447 T448 A449 R488 I492 V531
Gene Ontology
Molecular Function
GO:0005222 intracellularly cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0022843 voltage-gated monoatomic cation channel activity
GO:0030552 cAMP binding
GO:0042802 identical protein binding
GO:0140232 intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
Biological Process
GO:0003254 regulation of membrane depolarization
GO:0006814 sodium ion transport
GO:0019228 neuronal action potential
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045176 apical protein localization
GO:0046549 retinal cone cell development
GO:0051289 protein homotetramerization
GO:0051867 general adaptation syndrome, behavioral process
GO:0060078 regulation of postsynaptic membrane potential
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0034702 monoatomic ion channel complex
GO:0045211 postsynaptic membrane
GO:0048787 presynaptic active zone membrane
GO:0098855 HCN channel complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t4m, PDBe:8t4m, PDBj:8t4m
PDBsum8t4m
PubMed38890331
UniProtO60741|HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Gene Name=HCN1)

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