Structure of PDB 8t2r Chain D

Receptor sequence

>8t2rD (length=388) Species: 39491 (Agathobacter rectalis)

SNLMEQILSSDNLNRAYLQVVRNKGAEGVDGMKYTELKEHLAKNGETIKG
QLRTRKYKPQPGVPTVTDRFIQQAIAQVLTPIYEEQFHDHSYGFRPNRCA
QQAILTALNIMNDGNDWIVDIDLEKFFDTVNHDKLMTLIGRTIKDGDVIS
IVRKYLVSGNLSPLLANIMLNELDKEMEKRGLNFVRYADDCIIMVGSEMS
ANRVMRNISRFIEEKLGLKVNMTKSKVDRPSGLKYLGFGFYFDPRAHQFK
AKPHAKSVAKFKKRMKELTCRSWGVSNSYKVEKLNQLIRGWINYFKIGSM
KTLCKELDSRIRYRLRMCIWKQWKTPQNQEKNLVKLGIDRNTARRVAYTG
KRIAYVCNKGAVNVAISNKRLASFGLISMLDYYIEKCV

3D structure

• PDB: 8t2r Structural insights into intron catalysis and dynamics during splicing
• Chain: D
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.49: RNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	N378 R381 R382 V383 Y385 K388 R389 Y392 G397 A398	N341 R344 R345 V346 Y348 K351 R352 Y355 G360 A361
BS02	rna	D	R58 D152 T156 R160 S169 R172 K173 R217 L219 V232 G233 S234 M236 S237 R240 V241 R243 N244 K300 K303 R308 S309 G311 R347 Y350 R351 M354 K358 K361 R389 A391	R55 D133 T137 R141 S150 R153 K154 R180 L182 V195 G196 S197 M199 S200 R203 V204 R206 N207 K263 K266 R271 S272 G274 R310 Y313 R314 M317 K321 K324 R352 A354

Gene Ontology

Molecular Function

• GO:0003964 RNA-directed DNA polymerase activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process
• GO:0006974 DNA damage response

External links

• PDB: RCSB:8t2r, PDBe:8t2r, PDBj:8t2r
• PDBsum: 8t2r
• PubMed: 37993708
• UniProt: A0A173ZME3