Structure of PDB 8syc Chain D

Receptor sequence
>8sycD (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
VEEYDSLIEKMSNWNFPIFELVEKMGEDSGRILSQVMYTLFQDTGLLEIF
KIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQI
HIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNEF
LVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFERF
RFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVC
IKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSDP
QLAKLQESFITHIVGPLCNSYDAAGLLPGQWLRIFCQLMHHLTENHKIWK
ENLYF
3D structure
PDB8syc Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D H741 H821 D822 D937 H78 H139 D140 D255
BS02 X5W D Y736 H737 D822 H825 G940 W951 I955 F959 L987 Q988 F991 Y73 H74 D140 H143 G258 W269 I273 F277 L305 Q306 F309
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8syc, PDBe:8syc, PDBj:8syc
PDBsum8syc
PubMed38284310
UniProtQ13370|PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Gene Name=PDE3B)

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