Structure of PDB 8ssr Chain D

Receptor sequence

>8ssrD (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]

KPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHM
RTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIAR
KSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCD
QCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDP
NFVPAAFVCSKCGKTFTRRNTMARHADNCA

3D structure

PDB

8ssr Structures of CTCF-DNA complexes including all 11 zinc fingers.

Chain

Resolution

3.14 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	E362 S364 K365 R368 Y392 R457 R470 K490 R508 Q536 R567 N568	E14 S16 K17 R20 Y44 R109 R122 K142 R160 Q188 R219 N220
BS02	dna	D	Y386 R389 K393 R396 H397 T400 K405 Q418 K429 R448 D451 H455 Q459 R479 Y502 K530 F532 Q536 L537 M540 R544 R566	Y38 R41 K45 R48 H49 T52 K57 Q70 K81 R100 D103 H107 Q111 R131 Y154 K182 F184 Q188 L189 M192 R196 R218
BS03	ZN	D	H369 H373	H21 H25
BS04	ZN	D	C381 C384 H397 H401	C33 C36 H49 H53
BS05	ZN	D	C409 H425 H430	C61 H77 H82
BS06	ZN	D	C439 H455 H460	C91 H107 H112
BS07	ZN	D	C469 C472 H485 H489	C121 C124 H137 H141
BS08	ZN	D	C500 H513 H517	C152 H165 H169
BS09	ZN	D	C525 C528 H541 H546	C177 C180 H193 H198
BS10	ZN	D	C560 H573 C577	C212 H225 C229

External links

PDB	RCSB:8ssr, PDBe:8ssr, PDBj:8ssr
PDBsum	8ssr
PubMed	37439339
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

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