Structure of PDB 8sso Chain D

Receptor sequence
>8ssoD (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH
QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS
KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFG
WSVHTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET
YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANS
SK
3D structure
PDB8sso A biophysical framework for double-drugging kinases.
ChainD
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 627 D L139 V147 K162 Y212 A213 P214 G216 N261 L263 V279 L13 V21 K36 Y86 A87 P88 G90 N135 L137 V153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0051321 meiotic cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:8sso, PDBe:8sso, PDBj:8sso
PDBsum8sso
PubMed37590418
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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