Structure of PDB 8sse Chain D

Receptor sequence
>8sseD (length=506) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PLLERLKRRVVEGRKQGLEADLEEALKAGHKPLDLINGPLLAGMKEVGDL
FGAGKMQLPFVLQAAEVMKRAVAYLEPHMEKEGKGTLVLATVKGDVHDIG
KNLVDIILSNNGYRVVNLGIKVPIEEILKAVEAHKPHAVGMSGLLVKSTL
VMKENLEYMRDRGYTLPVILGGAALTRSYVEELRAIYPNVYYAEDAFEGL
RLMEELTGHAPPELTRRARPVGEAPAVPRPPFFGVRVEEGLDLATIAHYV
NKLALYRGQWGYSRKGLSREAWQALVEREAEPVFQRLLKEAMAEGWLEPK
VLYGFFPVAREGEELLVFSPETGEVLERFRFPRQKGGGLSLVDYFRPRFA
APLGDEADWMPKEAFRAGARDVLGVQLVTMGEAPSRKAQALFASGAYQDY
LFVHGFSVEMTEALAEYWHKRMRQMWGIAHQDATEIQKLFQQGYQGARYS
FGYPACPDLADQAKLDRLMGFHRVGVRLTENFQLEPEHATSALVVHHPEA
RYFSVD
3D structure
PDB8sse Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo
ChainD
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.13: methionine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 D H761 I763 G764 V768 M805 S806 L809 V810 I833 G835 G836 A837 A860 Q938 S1129 F1130 G1131 Y1132 Q1162 L1163 E1166 A1168 T1169 S1170 H97 I99 G100 V104 M141 S142 L145 V146 I169 G171 G172 A173 A196 Q259 S450 F451 G452 Y453 Q483 L484 E487 A489 T490 S491
Gene Ontology
Molecular Function
GO:0008705 methionine synthase activity
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0009086 methionine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8sse, PDBe:8sse, PDBj:8sse
PDBsum8sse
PubMed37821448
UniProtQ5SKM5

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