Structure of PDB 8ss7 Chain D
Receptor sequence
>8ss7D (length=401) Species:
10116
(Rattus norvegicus) [
Search protein sequence
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QKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF
LVSRFSPYNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTL
IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR
RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNE
YIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLD
KLKNKWWYDKGECGAEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY
K
3D structure
PDB
8ss7
Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.
Chain
D
Resolution
2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
6ZP
D
S785 A786
S369 A370
BS02
6ZP
D
S510 S516 F517 D519 P520 L620 F623 L624 N791
S119 S125 F126 D128 P129 L210 F213 L214 N375
BS03
ZK1
D
E402 Y450 P478 T480 R485 G653 S654 T686 E705 Y732
E11 Y59 P87 T89 R94 G243 S244 T276 E295 Y322
BS04
CLR
D
E813 Y816
E397 Y400
Gene Ontology
Molecular Function
GO:0000149
SNARE binding
GO:0001540
amyloid-beta binding
GO:0004970
glutamate-gated receptor activity
GO:0004971
AMPA glutamate receptor activity
GO:0005230
extracellular ligand-gated monoatomic ion channel activity
GO:0005234
extracellularly glutamate-gated ion channel activity
GO:0005515
protein binding
GO:0008092
cytoskeletal protein binding
GO:0015276
ligand-gated monoatomic ion channel activity
GO:0015277
kainate selective glutamate receptor activity
GO:0019865
immunoglobulin binding
GO:0019901
protein kinase binding
GO:0022849
glutamate-gated calcium ion channel activity
GO:0030165
PDZ domain binding
GO:0035254
glutamate receptor binding
GO:0035255
ionotropic glutamate receptor binding
GO:0038023
signaling receptor activity
GO:0042802
identical protein binding
GO:0044877
protein-containing complex binding
GO:0097110
scaffold protein binding
GO:0099094
ligand-gated monoatomic cation channel activity
GO:0099507
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO:1904315
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
GO:0001919
regulation of receptor recycling
GO:0006816
calcium ion transport
GO:0007268
chemical synaptic transmission
GO:0010226
response to lithium ion
GO:0019722
calcium-mediated signaling
GO:0021987
cerebral cortex development
GO:0031623
receptor internalization
GO:0034220
monoatomic ion transmembrane transport
GO:0035235
ionotropic glutamate receptor signaling pathway
GO:0035249
synaptic transmission, glutamatergic
GO:0045184
establishment of protein localization
GO:0050804
modulation of chemical synaptic transmission
GO:0050806
positive regulation of synaptic transmission
GO:0051262
protein tetramerization
GO:0051966
regulation of synaptic transmission, glutamatergic
GO:0060078
regulation of postsynaptic membrane potential
GO:0060079
excitatory postsynaptic potential
GO:0060992
response to fungicide
GO:0098655
monoatomic cation transmembrane transport
GO:0099505
regulation of presynaptic membrane potential
GO:1905430
cellular response to glycine
GO:1990416
cellular response to brain-derived neurotrophic factor stimulus
Cellular Component
GO:0005783
endoplasmic reticulum
GO:0005886
plasma membrane
GO:0008021
synaptic vesicle
GO:0008328
ionotropic glutamate receptor complex
GO:0009986
cell surface
GO:0014069
postsynaptic density
GO:0016020
membrane
GO:0030424
axon
GO:0030425
dendrite
GO:0030426
growth cone
GO:0030672
synaptic vesicle membrane
GO:0032279
asymmetric synapse
GO:0032281
AMPA glutamate receptor complex
GO:0032590
dendrite membrane
GO:0032839
dendrite cytoplasm
GO:0032991
protein-containing complex
GO:0036477
somatodendritic compartment
GO:0042734
presynaptic membrane
GO:0043005
neuron projection
GO:0043025
neuronal cell body
GO:0043195
terminal bouton
GO:0043197
dendritic spine
GO:0043198
dendritic shaft
GO:0043204
perikaryon
GO:0044326
dendritic spine neck
GO:0044327
dendritic spine head
GO:0045202
synapse
GO:0045211
postsynaptic membrane
GO:0048787
presynaptic active zone membrane
GO:0097060
synaptic membrane
GO:0098685
Schaffer collateral - CA1 synapse
GO:0098793
presynapse
GO:0098839
postsynaptic density membrane
GO:0098978
glutamatergic synapse
GO:0099544
perisynaptic space
GO:0106033
spine synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:8ss7
,
PDBe:8ss7
,
PDBj:8ss7
PDBsum
8ss7
PubMed
37653241
UniProt
P19491
|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2);
Q8VHW8
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