Structure of PDB 8srb Chain D

Receptor sequence
>8srbD (length=1349) Species: 946362 (Salpingoeca rosetta) [Search protein sequence]
IRQSVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTAWG
TLRFPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLILSV
TGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQIME
ALSKTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPPKT
TPLDDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVVQG
GPGTLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSYTI
DDLRQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDEFD
DCILKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAACI
NDNLMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPSFA
LAIEELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVLRM
DQIFARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAICL
DRFRMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKMQH
NAKKFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAKSL
AFLSHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINFSELRR
KFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILLVWF
VALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDPSNQ
DSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVSTFVF
LLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDDLNS
EANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDTYMK
VQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLCGVH
TQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTNDNV
VQAMGMMDQLLEHMISFRFSLDQQAEWYVPPEEYPKSGGVKRYLIDASMV
PLSIMCPSYDPVEYTHPSVAAQPVWADPADPRKIKFNVKDEVNGKVVDRT
SCHPSGISIDSNTGRPINPWGRTGMTGRGLLGKWGVNQAADTVVTRWKRS
PDGSILERDGKKVLEFVAIQRQDNKMWAIPGGFVDNGEDVALTSGREFME
EALGMGSAESKDSLAALFSSGTIVARIYCEDPRNTDNAWVETTCVNFHDE
SGRHAARLKLQGGDDAEHARWMMVHGGLNLFASHRTLLQHVTSALNAYF
3D structure
PDB8srb Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
ChainD
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR D F976 Y979 F883 Y886
BS02 CLR D F1003 R1012 P1015 F1016 F910 R919 P922 F923
BS03 CLR D E1009 R1012 M1013 F1016 E916 R919 M920 F923
BS04 APR D T148 G149 A151 T184 F268 G298 P299 T301 T101 G102 A104 T137 F221 G251 P252 T254
BS05 CLR D I902 F905 I809 F812
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8srb, PDBe:8srb, PDBj:8srb
PDBsum8srb
PubMed38773335
UniProtF2UB89

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