Structure of PDB 8sr9 Chain D

Receptor sequence
>8sr9D (length=1352) Species: 946362 (Salpingoeca rosetta) [Search protein sequence]
AMIRQSVAAKTLLIENEDGKGSTRMEVQDFMKRFHMHASEDDKTGSPSTA
WGTLRFPTKEATAPYLRLSVNDDPEDALLFVKAMLAQKYGETYDRPSLIL
SVTGGARNFTLPPRLETAIAKGLRLAAQRTNAWVVTGGTNTGVMKLTGQI
MEALSKTQSHFIPPTIGIATYGVIIGGDDMTRGEPPKIGLEYEMHKKDPP
KTTPLDDNHNLFLLVDDGSTNKFGKEIKFRAAFENAAGQAFAAPVVTIVV
QGGPGTLGTALQAVRQGTPIVVVDGSGLAADVLAYAYNFMHNPLTRFKSY
TIDDLRQKVAQTFNPKSSQQLTNLLDSALECVQDPNLVVVYSLQESGIDE
FDDCILKAIFSSQGKLGNKLKQAMYFDQLDVAKRALSEASKNGQHNEIAA
CINDNLMAAMMHNKPHFVELYLGFDAKIYELKPSEEVAKTNITALDELPS
FALAIEELYKREAKKPHSHVQRLVSLSNTDVLGRHYRGRDLANTRAYNVL
RMDQIFARLVSKDFSVNRDFTIYDSKYDKVPGIQFRRTAQASHMLFLWAI
CLDRFRMARHFWLIGDQSIINALVASRILERLSTHRALQGPHLAEERAKM
QHNAKKFEELAVGVLGECHGSDSHMASEMLHSKNDMFNKKNAINIAYDAK
SLAFLSHPATQSVINADWYGHLKSVTSFWAVLFAFFFPFFVLPFINGAHR
LRRKFAKFYSAPYTRFISDLLSHFVLCVVTSYFVLDKLEDTISAIEWILL
VWFVALLLEELRQMIFCDGIAEYISDTWNRLDLIMITLFFVGFFTHASDP
SNQDSKVVSKGIHAFLVVVLWLRFMRYYALSKNLGPKLIMMMEMMKDVST
FVFLLLIFLIGYGVAAQSLLSPDEDFSSRTFIGVLFRPYFQIYGELFLDD
LNSEANCLGDTPFTECSRETVRMVPFFLAVYILGSNVLLVNLLIAMFNDT
YMKVQEAAEDLWRKQNYELCAEYKDRPFLPAPFILLAHVHMLFMRLLRLC
GVHTQEHEKIQDDETKRKITTFEELNTDKFLRRWERERQEMLEARVKMTN
DNVVQAMGMMDQLLEHMISFRFSLDQQAEWYVPPEEYPKSGGVKRYLIDA
SMVPLSIMCPSYDPVEYTHPSVAAQPVWADPADPRKIKFNVKDEVNGKVV
DRTSCHPSGISIDSNTGRPINPWGRTGMTGRGLLGKWGVNQAADTVVTRW
KRSPDGSILERDGKKVLEFVAIQRQDNKMWAIPGGFVDNGEDVALTSGRE
FMEEALGMGSAESKDSLAALFSSGTIVARIYCEDPRNTDNAWVETTCVNF
HDESGRHAARLKLQGGDDAEHARWMMVHGGLNLFASHRTLLQHVTSALNA
YF
3D structure
PDB8sr9 Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
ChainD
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR D F976 Y979 F886 Y889
BS02 CLR D F1003 R1012 P1015 F1016 F913 R922 P925 F926
BS03 CLR D E1009 M1013 F1016 E919 M923 F926
BS04 MG D E850 N869 E760 N779
BS05 MG D W620 L621 G623 W562 L563 G565
BS06 CLR D L878 V898 I902 L788 V808 I812
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sr9, PDBe:8sr9, PDBj:8sr9
PDBsum8sr9
PubMed38773335
UniProtF2UB89

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